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British Journal of Anaesthesia, 2002, Vol. 89, No. 2 216-220
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Editorial

Editorial III

Inflammation and the coagulation system

Nigel R. Webster{dagger},1

1 Academic Unit of Anaesthesia and Intensive Care Institute of Medical Sciences Foresterhill Aberdeen AB25 2ZD UK

{dagger}Declaration of interest: Professor N. R. Webster is a member of the Drotrecogin alfa (activated) Advisory Board of Eli Lilly and Company Ltd.

The first 150 words of the full text of this article appear below.

The syndrome of multiple organ failure has been recognised for at least 30 yr and is one of the leading causes of mortality in intensive care. Patients develop a spectrum of different organs being affected, as well as degrees of severity of failure, and the term multi-organ dysfunction syndrome (MODS) is now more commonly used.1 The aetiology of MODS is still not clear although it is considered to result from severe and generalized inflammation. There are two current theories: abnormal cellular metabolism, and abnormal tissue blood flow. Abnormalities of cellular metabolism are common, and lactic acidosis in severe sepsis is frequently observed. It is believed that the lactate accumulation results from widespread anaerobic respiration caused by either alterations in the microcirculation (oxygen delivery to tissues) or abnormalities in oxygen utilization by the tissues. The simple idea that anaerobic metabolism occurs as a result of tissue hypoxia and hypoperfusion is no . . . [Full Text of this Article]

Heparin

Inhibitors of TF activation

Antithrombin III

Protein C

Conclusion


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