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British Journal of Anaesthesia, 2002, Vol. 88, No. 6 866-868
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Effects of xenon on acetylcholine release in the rat cerebral cortex in vivo

T. Shichino*,1, M. Murakawa2, T. Adachi1, Y. Miyazaki1, H. Segawa1, K. Fukuda1 and K. Mori1

1Department of Anesthesia, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. 2Department of Anesthesiology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan*Corresponding author

Background. We have reported previously the effects of several anaesthetics on cholinergic activity in the central nervous system (CNS). In this study, we report the effects of xenon on cholinergic cell activity.

Methods. Using in vivo brain microdialysis, we measured acetylcholine (ACh) release in the rat cerebral cortex in vivo during xenon anaesthesia.

Results. Xenon induced an initial increase in ACh release, followed by a gradual decrease. The level of Ach release at 40 min of xenon administration was significantly higher than the control.

Conclusions. Xenon activates CNS cholinergic cell activity followed by development of acute tolerance.

Br J Anaesth 2002; 88: 866–8


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