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British Journal of Anaesthesia, 2002, Vol. 88, No. 4 470-472
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Editorial

Editorial II

Haemodilution enhances coagulation

T. G. Ruttmann1

1Department of Anaesthesia, University of Cape Town Medical School, Observatory, Cape 7925, South Africa.

The effect of haemodilution on enhancing coagulation is well described. In this issue, Ng, Lam and Chan1 have avoided all the confounding variables of the stress response induced by surgery, and have identified enhanced coagulation to be a result of the haemodilution itself. This was achieved by comparing the onset of coagulation in two groups undergoing anaesthesia for hepatobiliary surgery: one group received fluid after starting anaesthesia; the other, acting as the control group, received no intravenous fluid after starting anaesthesia. The two groups were compared, using Thrombelastograph® and routine tests, before commencing any surgical stimulus. In doing so, the enhancement of clot formation after haemodilution has been reconfirmed.

In analysing the effect of enhanced coagulation occurring with haemodilution, the entire clotting cascade has been explored in order to define exactly at which point, and through which mechanism, this occurs. There may well be many factors that have an impact . . . [Full Text of this Article]

Acknowledgement

References


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