Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Beaussier, M.
Right arrow Articles by Coriat, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beaussier, M.
Right arrow Articles by Coriat, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2002, Vol. 88, No. 3 399-407
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Laboratory Investigations

Role of nitric oxide and cyclooxygenase pathways in the coronary vascular effects of halothane, isoflurane and desflurane in red blood cell-perfused isolated rabbit hearts

M. Beaussier*, S. Mouren, R. Souktani, M. Arthaud, L. Massias, E. Vicaut, A. Lienhart and P. Coriat

Department of Anesthesia and Intensive Care, Pitié-Salpétrière Hospital, Paris, France *Corresponding author: Département d’Anesthésie-Réanimation chirurgicale, St Antoine Hospital, 184 rue du Fbg St Antoine, F-75012 Paris, France

Background. The coronary vascular endothelium could mediate some of the coronary effects of halogenated anaesthetic agents. The role of the endothelial vasodilator substances nitric oxide (NO) and prostaglandins (PGs) in the coronary effects of halothane and isoflurane remains to be determined and has not been investigated for desflurane. In this study, the roles of NO and cyclooxygenase pathways in the coronary effects of halothane, isoflurane and desflurane were studied in isolated red blood cell-perfused rabbit hearts.

Methods. Rabbit hearts were perfused by a Langendorf technique with red blood cells mixed with modified Krebs–Henseleit buffer. Coronary blood flow (CBF), oxygen consumption and myocardial performance were evaluated during exposure to 0.5, 1 and 2 rabbit minimum alveolar concentrations of halothane, desflurane and isoflurane. Thereafter, the same protocol was applied with the addition of NG-nitro-L-arginine (L-NNA), indomethacin or a combination of both inhibitors.

Results. Similar and significant increases in CBF were observed with increasing concentrations of isoflurane and desflurane. In contrast, CBF did not change with halothane. The combination of the two antagonists abolished desflurane-induced vasodilation, whereas it did not change the isoflurane-mediated increase in CBF. Halothane-induced vasoconstriction was observed in the presence of a combination of indomethacin with L-NNA.

Conclusions. Halothane and desflurane induce the release of vasodilating prostaglandins and NO in rabbit coronary arteries. In contrast, these mediators are not involved in the coronary vasodilating properties of isoflurane.

Br J Anaesth 2002; 88: 399–407


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
H. Iwasaki, K. Fukushima, A. Kawamoto, K. Umetani, A. Oyamada, S. Hayashi, T. Matsumoto, M. Ishikawa, T. Shibata, H. Nishimura, et al.
Synchrotron Radiation Coronary Microangiography for Morphometric and Physiological Evaluation of Myocardial Neovascularization Induced by Endothelial Progenitor Cell Transplantation
Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1326 - 1333.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
T. A. Stekiel, Z. J. Bosnjak, and W. J. Stekiel
Effects of General Anesthetics on Regulation of the Peripheral Vasculature
Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 311 - 331.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.