Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (49)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Rømsing, J.
Right arrow Articles by Dahl, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rømsing, J.
Right arrow Articles by Dahl, J. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2002, Vol. 88, No. 2 215-226
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia

J. Rømsing*,1, S. Møiniche2 and J. B. Dahl2

1Department of Pharmaceutics, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK-2100 Copenhagen, Denmark. 2Department of Anaesthesiology, Herlev University Hospital, Herlev, Denmark.*Corresponding author

Background. We have reviewed the analgesic efficacies of rectal and parenteral paracetamol and tested the evidence for a possible additive analgesic effect of the combination of paracetamol with a non-steroidal anti-inflammatory drug (NSAID) in postoperative pain.

Methods. Randomized controlled trials were evaluated. Outcome measures were pain scores and demand for supplementary analgesia.

Results. Eight studies compared rectal paracetamol with placebo. One study of single-dose administration of rectal paracetamol 40–60 mg kg–1 and three studies of repeat dosing with 14–20 mg kg–1 showed significant analgesic efficacy, while studies of a single dose of 10–20 mg kg–1 were negative. Ten studies compared parenteral paracetamol with placebo and eight studies showed improved pain relief with paracetamol. Of the nine studies comparing paracetamol with a combination of paracetamol and an NSAID, six studies showed improved pain relief for the combination while only two of the six studies comparing an NSAID with a combination of an NSAID and paracetamol showed improved pain relief for the combination.

Conclusions. Considering the few studies available, evidence was found of a clinically relevant analgesic effect of rectal and parenteral paracetamol. Concurrent use of paracetamol and an NSAID was superior to paracetamol alone but no evidence was found of superior analgesic effect of the combination compared with the NSAID alone.

Br J Anaesth 2002; 88: 215–26


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
P. F. White, H. Kehlet, J. M. Neal, T. Schricker, D. B. Carr, F. Carli, and the Fast-Track Surgery Study Group
The Role of the Anesthesiologist in Fast-Track Surgery: From Multimodal Analgesia to Perioperative Medical Care
Anesth. Analg., June 1, 2007; 104(6): 1380 - 1396.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
E. Munsterhjelm, T. T. Niemi, O. Ylikorkala, P. J. Neuvonen, and P. H. Rosenberg
Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers
Br. J. Anaesth., August 1, 2006; 97(2): 226 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. Hiller, O. A. Meretoja, R. Korpela, S. Piiparinen, and T. Taivainen
The analgesic efficacy of acetaminophen, ketoprofen, or their combination for pediatric surgical patients having soft tissue or orthopedic procedures.
Anesth. Analg., May 1, 2006; 102(5): 1365 - 1371.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. Benhamou, J.-X. Mazoit, and A. Marcou
The Combination of Tramadol and Morphine May Be Recommended for Postoperative Analgesia
Anesth. Analg., December 1, 2005; 101(6): 1885 - 1885.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
F. Bonnet and E. Marret
Influence of anaesthetic and analgesic techniques on outcome after surgery
Br. J. Anaesth., July 1, 2005; 95(1): 52 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Beaussier, H. Weickmans, C. Paugam, S. Lavazais, J. P. Baechle, P. Goater, A. Buffin, J. F. Loriferne, J. F. Perier, J. P. Didelot, et al.
A Randomized, Double-Blind Comparison Between Parecoxib Sodium and Propacetamol for Parenteral Postoperative Analgesia After Inguinal Hernia Repair in Adult Patients
Anesth. Analg., May 1, 2005; 100(5): 1309 - 1315.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
C. Remy, E. Marret, and F. Bonnet
Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials
Br. J. Anaesth., April 1, 2005; 94(4): 505 - 513.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
E. Munsterhjelm, T. T. Niemi, M. T. Syrjala, O. Ylikorkala, and P. H. Rosenberg
Propacetamol augments inhibition of platelet function by diclofenac in volunteers
Br. J. Anaesth., September 1, 2003; 91(3): 357 - 362.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
H. Viitanen, N. Tuominen, H. Vaaraniemi, E. Nikanne, and P. Annila
Analgesic efficacy of rectal acetaminophen and ibuprofen alone or in combination for paediatric day-case adenoidectomy{dagger}
Br. J. Anaesth., September 1, 2003; 91(3): 363 - 367.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.