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British Journal of Anaesthesia, 2002, Vol. 88, No. 1 139-140
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Case Reports

Skin necrosis following injection of non-steroidal anti-inflammatory drug

A. M. McGee* and P. M. Davison

Department of Plastic Surgery, North Staffordshire NHS Trust Hospital, Hartshill, Stoke-on-Trent, UK*Corresponding author

We report two patients who developed skin necrosis following an intramuscular injection of non-steroidal anti-inflammatory drug into the anteriolateral area of their thigh. Both patients required further multiple operations and one developed life threatening septicaemia. They were left with disfiguring scars. Skin necrosis, although rare, is a recognized adverse reaction to intramuscular non-steroidal anti-inflammatory injections. It is likely that the injections were, unwittingly, administered subcutaneously. It is important to ensure intra-muscular administration, with an appropriate needle length.

Br J Anaesthesia 2002; 88: 139–40


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