Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Blanc, P.
Right arrow Articles by Lehot, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blanc, P.
Right arrow Articles by Lehot, J. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2001, Vol. 87, No. 6 848-854
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Safety of oral nicorandil before coronary artery bypass graft surgery{dagger}

P. Blanc1, A. Aouifi1, H. Bouvier1, P. Joseph1, P. Chiari1, M. Ovize2, C. Girard1,4, O. Jegaden3, Y. Khder5 and J. J. Lehot1

1Service d’Anesthésie-Réanimation, Hôpital Cardiovasculaire Louis Pradel, 28 avenue du Doyen Lépine, BP Lyon-Montchat, F-69394 Lyon Cedex 03, France. 2Service de Cardiologie D, Hôpital Cardio-vasculaire Louis Pradel, 28 avenue du Doyen Lépine, BP Lyon-Montchat, F-69394 Lyon Cedex 03, France. 3Service de Chirurgie Cardiaque B, Hôpital Cardiovasculaire Louis Pradel, 28 avenue du Doyen Lépine, BP Lyon-Montchat, F-69394 Lyon Cedex 03, France 4Present address: CHU Hôpital du Bocage, BP 1542, F-21034 Dijon Cedex, France. 5Present address: MERCK-LIPHA Santé, Département de Recherche Clinique, 116 rue Carnot, BP 60, F-92152 Suresnes Cedex, France*Corresponding author

{dagger}This work was presented as a poster during the Annual Meeting of the American Society of Anesthesiologists (ASA), San Francisco (USA), October 14–18, 2000.

Nicorandil is a KATP channel opener used to treat angina. It is cardioprotective and a vasodilator. We conducted a prospective, randomized, double-blind, placebo-controlled study to assess oral nicorandil in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). Twenty-two patients received nicorandil (10 mg twice a day) and 23 patients received placebo. Haemodynamic data were recorded before induction of anaesthesia (T0), 5 and 20 min after starting mechanical ventilation (T1, T2), before aortic cannulation (T3), after 30 min of CPB (T4), 10 min after CPB (T5) and after 3, 8 and 18 h in the intensive care unit (T6, T7, T8). Serum proteins (creatine kinase metabolite and cardiac troponin I) were measured before and 8 and 18 h after surgery. Haemodynamic values did not differ between the two groups. There was no tachycardia during the study, no significant difference in hypotensive episodes, ST segment changes and no changes in cardiac enzymes. Myocardial infarction after surgery was similar in the two groups. Vasoactive therapy was similar in the two groups. Nicorandil can be continued safely up to premedication without deleterious haemodynamic consequences, but a myocardial protective effect of nicorandil in CABG surgery was not found.

Br J Anaesth 2001; 87: 848–54


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
R. A. Kloner and S. H. Rezkalla
Preconditioning, postconditioning and their application to clinical cardiology
Cardiovasc Res, May 1, 2006; 70(2): 297 - 307.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.