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British Journal of Anaesthesia, 2001, Vol. 87, No. 4 588-592
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Prospective randomized, double-blind comparative study of dexamethasone, ondansetron, and ondansetron plus dexamethasone as prophylactic antiemetic therapy in patients undergoing day-case gynaecological surgery

R. Thomas* and N. Jones

Department of Anaesthetics, North Hampshire Hospital, Aldermaston Road, Basingstoke, Hampshire RG24 9NA, UK*Corresponding author: Shackleton Department of Anaesthetics, Southampton General Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK

{dagger} LMA® is the property of Intavent Limited.

Dexamethasone alone and in combination with selective 5-hydroxytryptamine receptor antagonists is of benefit in the prophylaxis of post-operative nausea and vomiting. In this study, the effectiveness of such a combination in comparison to either drug alone is investigated in day case gynaecological surgery. A total of 177 patients were randomized to three treatment groups: dexamethasone 8 mg, ondansetron 4 mg, and dexamethasone 8 mg plus ondansetron 4 mg. The only significant difference between groups was seen in the first 3 h when failure of prophylaxis was more frequent in patients who had received dexamethasone alone (P=0.0085; Fisher’s exact probability test). Confidence interval analysis indicates a modest treatment effect for the combination and the decision whether to perform a larger study depends upon whether such an effect is clinically relevant.

Br J Anaesth 2001; 87: 588–92


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