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British Journal of Anaesthesia, 2001, Vol. 87, No. 3 505-507
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia


Case Reports

Onset of propofol-induced burst suppression may be correctly detected as deepening of anaesthesia by approximate entropy but not by bispectral index

J. Bruhn*,1, T. W. Bouillon1 and S. L. Shafer1,2

1Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA, USA. 2Palo Alto VA Health Care Center, Palo Alto, CA, USA*Corresponding author: Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Str. 25, D-53105 Bonn, Germany

The bispectral index (BIS) is a complex EEG variable that combines several disparate descriptors of the EEG into a single value. Approximate entropy is a novel EEG measure that quantifies the regularity of a data time series such as EEG. We report two patients in which the EEG effect of propofol was quantified very similarly by BIS and approximate entropy. However, at the beginning of burst suppression of the EEG, BIS did not indicate an increased anaesthetic drug effect, while approximate entropy did.

Br J Anaesth 2001; 87: 505–7


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