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British Journal of Anaesthesia, 2001, Vol. 87, No. 3 497-498
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Arterial and mixed venous xenon blood concentrations in pigs during wash-in of inhalational anaesthesia{dagger}

M. Nalos1,2, U. Wachter*,1, A. Pittner1, M. Georgieff1, P. Radermacher1 and G. Froeba1

1Universitätsklinik für Anästhesiologie, Universität Ulm, Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Parkstrasse 11, D-89073 Ulm, Germany 2Present address: Anesteziologicko resuscitaèni klinika, Karlova Univerzita, CZ-30460 Plzen, Czech Republic*Corresponding author

There are no data available on the kinetics of blood concentrations of xenon during the wash-in phase of an inhalation anaesthesia aiming at 1 MAC end-expiratory concentration. Therefore, we anaesthetized eight pigs with continuous propofol and fentanyl and measured arterial, mixed venous and end-expiratory xenon concentrations by gas chromatography–mass spectrometry 1, 2, 3, 4, 5, 7, 10, 15, 20, 30, 60 and 120 min after starting the anaesthetic gas mixture [67% xenon/33% oxygen; 3 litre min–1 during the first 10 min, thereafter minimal flow with 0.48 (SD 0.03) litre min–1]. End-expiratory xenon concentrations plateaued (defined as <5% change from the preceding value) at 64 (6) vol% after 7 min, and arterial and mixed venous xenon concentrations after 5 and 15 min respectively. The highest arterio-venous concentration difference occurred after 3 min. Using the Fick principle, we calculated a mean xenon uptake of 3708 (829) and 9977 (3607) ml after 30 and 120 min respectively.

Br J Anaesth 2001; 87: 497–8


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