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British Journal of Anaesthesia, 2001, Vol. 87, No. 3 490-493
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Stress response during weaning after cardiac surgery

E. Calzia*, M. Koch, W. Stahl, P. Radermacher and A. Brinkmann

Department of Anaesthesiology, Section of Pathophysiology and Process Development, University of Ulm, D-89073 Ulm, Germany*Corresponding author

We compared the effects of weaning using synchronized intermittent mandatory ventilation (SIMV) with the use of biphasic positive airway pressure (BIPAP) on the stress response, oxygen uptake (V·O2) and work of breathing (WOB) in 10 patients after aortocoronary bypass surgery. All three ventilatory settings were investigated in each patient, for example, volume-controlled mechanical ventilation immediately before weaning was followed, in randomized order, by both SIMV and BIPAP. In addition to routine monitoring of continuous and respiratory state, we measured V·O2, WOB, and pressure–time product (PTP) as well as the plasma concentrations of epinephrine, norepinephrine, ACTH, cortisol, vasopressin, and prolactin. Although respiratory rate (f), WOB and PTP were greater with both SIMV and BIPAP when compared with control, other variables did not change with the ventilatory mode. In conclusion, weaning from mechanical ventilation using partial support modes does not affect the postoperative stress response in patients who have had uncomplicated cardiac surgery.

Br J Anaesth 2001; 87: 490–3


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