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British Journal of Anaesthesia, 2001, Vol. 87, No. 3 469-476
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Laboratory Investigations

Evolution of cerebral ischaemia induced by thromboembolism in rats detected by early sequential MR imaging

S. Ishikawa*,1, K. Yokoyama1, T. Kuroiwa2 and K. Makita1

1Department of Anesthesiology and Critical Care Medicine, and 2Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan*Corresponding author

Thromboembolic stroke appears to evolve in patients in a very complicated manner. The present study investigated the evolution of thromboembolic stroke in rats (n=9) using a 4.7-T MR imager. Under isoflurane anaesthesia, the rats received homologous blood clots into the right internal carotid artery. After thromboembolic stroke, lesion volume, which was defined and calculated, based on apparent diffusion coefficient maps, tended to increase gradually over the 6 h magnetic resonance imaging study. The largest percentage change in lesion volume was found at the early stage (40–100 min) of thromboembolism, and showed significant correlation with total percentage change in lesion volume (41.6 (SD 32.8%)) (r=0.77, P<0.05). In conclusion, marked enlargement or diminution of lesion volume may be observed at the early stage of thromboembolism. Thromboembolic stroke, which can be partly salvaged at the early stage, may likely evolve to a lesser extent thereafter.

Br J Anaesth 2001; 87: 469–76


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