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British Journal of Anaesthesia, 2001, Vol. 87, No. 2 306-308
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Case Reports

Two episodes of life-threatening anaphylaxis in the same patient to a chlorhexidine–sulphadiazine-coated central venous catheter

R. Stephens1, M. Mythen1, P. Kallis1, D. W. L. Davies1, W. Egner2 and A. Rickards3

1UCL Hospitals, The Middlesex Hospital, Mortimer Street, London W1N 8AA, UK. 2Supraregional Protein Reference Unit, Department of Immunology, Northern General Hospital NHS Trust, Sheffield S5 7YT, UK. 3The Heart Hospital, 50 Wimpole Street, London W1M 7DG, UK*Corresponding author

Chlorhexidine allergy has been described in the literature, mainly in Japanese individuals. Most reactions have been limited to the skin, mild in severity and a result of chlorhexidine containing solutions such as ‘Savlon’ (Novartis Consumer Health, Horesham, UK). We describe what we believe is the first reported case of anaphylaxis in a European patient to a chlorhexidine- sulphadiazine-coated central venous catheter.

Br J Anaesth 2001; 87: 306–8


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