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British Journal of Anaesthesia, 2001, Vol. 87, No. 2 266-271
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Laboratory Investigations

Aerosolized surfactant therapy for endotoxin-induced experimental acute respiratory distress syndrome in rats

K. Tashiro1, K. Yamada1, T. Konzaki1, K. Yamamoto1, S. Ohmura1, T. Kobayashi1 and Y. Suzuki2

1Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan. 2Department of Ultrastructural Research, Institute for Frontier Medical Sciences, Kyoto University, Japan*Corresponding author

We have compared the effects of inhalation of aerosolized surfactant on experimental acute respiratory distress syndrome. Escherichia coli endotoxin (55 (SD 20) mg kg–1) was injected into the tracheas of 36 adult rats anaesthetized and mechanically ventilated with pure oxygen. When the PaO2 decreased to 11.3 (3.3) kPa, the animals were randomly subjected to inhalation of aerosolized modified natural surfactant (MNS) for 0 min (control group), 30, 60, and 120 min. In the control group, PaO2 remained below 12 kPa for 180 min. In the groups receiving inhalation of surfactant for 30 and 60 min, PaO2 increased but decreased soon after termination of the inhalation. In contrast, PaO2 of the group receiving inhalation of surfactant for 120 min continued to increase, reaching 52.1 (12.5) kPa at 180 min (P<0.05 vs control). Thus, we conclude that improvement in gas exchange as a result of inhalation of MNS depends on the duration of inhalation.

Br J Anaesth 2001; 87: 266–71


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