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British Journal of Anaesthesia, 2001, Vol. 86, No. 6 874-876
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Orally administered clonidine significantly reduces pain during injection of propofol{dagger}

T. Yoshikawa1,2,3, Z. Wajima2, A. Ogura4, T. Inoue2 and R. Ogawa4

1Department of Anaesthesia, Hakujikai Memorial Hospital, 5-11-1 Shikahama, Adachi-ku, Tokyo 123-0864, Japan. 2Department of Anaesthesia, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan. 3Department of Anaesthesiology, Tokyo Jikeikai Medical School, Tokyo, Japan. 4Department of Anaesthesiology, Nippon Medical School, Tokyo, Japan*Corresponding author

{dagger}This work was carried out at Chiba Hokusoh Hospital, Nippon Medical School, 1715 Kamakasi Inba-mura, Inba-gun, Chiba 270–1694, Japan.

We examined the analgesic effects of orally administered clonidine on pain induced by injection of propofol (Diprivan; 2,6-diisopropyl phenol). Female patients (n=81) were randomly allocated to one of two groups: oral clonidine (5.5 µg kg–1) followed by i.v. propofol and a control group given placebo followed by i.v. propofol. The median pain score in the group receiving clonidine, using a four-point scale (0=no pain, 1=minimal pain, 2=moderate pain, 3=severe pain) was 1 (0–2), significantly lower than in the control group [2 (1–3), median (25–75 percentiles), P<0.001].

Br J Anaesth 2001; 86: 874–6


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