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British Journal of Anaesthesia, 2001, Vol. 86, No. 6 871-873
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Effect of intravenous magnesium on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers

S. Mikkelsen1, J. Dirks1, P. Fabricius1, K. L. Petersen2, M. C. Rowbotham2,3 and J. B. Dahl1

1Laboratory of Pain Physiology, Department of Anaesthesiology, Copenhagen University Hospital, Herlev, Copenhagen, Denmark. 2Department of Neurologyand 3Department of Anesthesiology, UCSF Pain Clinical Research Center, University of California, San Francisco, CA 94115, USA*Corresponding author

We investigated the effects of i.v. magnesium on secondary hyperalgesia following heat/capsaicin stimulation in human volunteers. Twenty-five volunteers were included in this double blind, randomized, crossover study. Sensitization was induced in the volunteers, who were then subjected to either i.v. saline or magnesium sulphate. No analgesic or antihyperalgesic effect could be demonstrated in sensitized skin during infusion of magnesium. In contrast, painfulness of thermal stimulation was increased in normal skin. These results suggest that i.v. magnesium has no important analgesic effects in clinically relevant doses.

Br J Anaesth 2001; 86: 871–3


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