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British Journal of Anaesthesia, 2001, Vol. 86, No. 5 693-703
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Tissue/blood and tissue/water partition coefficients for propofol in sheep{dagger},{ddagger}

B. M. Q. Weaver1,4, G. E. Staddon2,5 and W. W. Mapleson3

1The Veterinary School, University of Bristol, Langford, Bristol BS18 7DU, UK. 2Department of Medical Physics and Bioengineering, Bristol General Hospital, Bristol BS1 6SY, UK. 3Department of Anaesthetics and Intensive Care Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, UK 4Present address: 79 Sandford Road, Winscombe, North Somerset BS25 1JJ, UK 5Present address: 17 Shaldon Road, Horfield, Bristol BS7 9NN, UK*Corresponding author

{dagger}A provisional analysis of loss of propofol from tissue samples was presented to the Anaesthetic Research Society Meeting, Dundee, July 1998 (Br J Anaesth 1998; 81: 630–1).{ddagger}Declaration of interest: The in vivo work for this study was carried out in the Wellcome Comparative Anaesthetic Laboratory, which was provided by the Wellcome Trust. Financial support was provided by the Perry Foundation and the propofol was generously supplied by Imperial Chemical Industries Limited (now Astra-Zeneca).

The primary objective of this study was to determine in vivo tissue/blood partition coefficients of propofol for use in physiological modelling of its pharmacokinetics. The sheep was used as an animal model. In the main series of experiments, crossbred ewes received a bolus of propofol 1% (Diprivan) followed by an infusion during which blood concentrations were measured at intervals. After 2 h, the sheep were killed with an injection of potassium chloride, and tissue samples were taken for storage at –20°C and subsequent analysis. Tissue/blood partition coefficients depend on the amount of triglyceride which accumulates in blood from the propofol vehicle; for blood, free of added triglyceride, the following coefficients were calculated: brain, 3.23; heart, 5.94; kidney, 2.46; spleen, 1.86; semimembranosus muscle, >=1.61; triceps muscle, >=1.47. Calculated tissue/water coefficients were 35 times greater. There was indirect evidence of extraction of propofol by the lungs.

Br J Anaesth 2001; 86: 693–703


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