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British Journal of Anaesthesia, 2001, Vol. 86, No. 3 361-365
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Recovery from propofol anaesthesia supplemented with remifentanil

R. A. O’Hare, R. K. Mirakhur, J. E. Reid, D. S. Breslin and A. Hayes

Department of Anaesthetics and Intensive Care Medicine, The Queen’s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK*Corresponding author

{dagger} LMA® is the property of Intavent Limited.

We have examined the effects on recovery end-points of supplementation of a propofol-based anaesthetic with remifentanil. After induction of anaesthesia with propofol and remifentanil 1.0 µg kg–1, 15 patients each were randomly allocated to target plasma propofol concentrations of 2, 3, 4 or 5 µg ml–1 for maintenance of anaesthesia. Remifentanil was administered by infusion for supplementation in doses required for maintenance of adequate anaesthesia. All patients received 50% nitrous oxide in oxygen and ventilation was controlled. The total amount of drugs used and times to different recovery end-points were recorded. Cognitive function was also assessed using a Mini-Mental State questionnaire. The median dose of remifentanil for maintenance of adequate anaesthesia (excluding the initial bolus dose) in the four groups was 0.21, 0.15, 0.11 and 0.13 µg kg–1 min–1 respectively (P=0.0026). The median times to eye opening and orientation were shortest in the 2 µg ml–1 group [6.0 and 6.5 min, 8.5 and 10.8 min, 13.4 and 15.8 min, and 14.2 and 19.5 min respectively in the propofol 2, 3, 4, and 5 µg ml–1 groups respectively (P<0.001)]. The times to discharge from the recovery ward and the Mini-Mental State scores were not significantly different.

Br J Anaesth 2001; 86: 361–5


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