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British Journal of Anaesthesia, 2001, Vol. 86, No. 3 345-348
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Compound A production from sevoflurane is not less when KOH-free absorbent is used in a closed-circuit lung model system

L. Versichelen*,1, M. P. Bouche2, M. Struys1, J. Van Bocxlaer3, E. Mortier1, A. P. de Leenheer2 and G. Rolly1

1Department of Anaesthesia, Ghent University, De Pintelaan 185, Gent, Belgium. 2Laboratory of Toxicology, Ghent University, Harelbekestraat 72, B-9000 Gent, Belgium. 3Laboratory of Medical Biochemistry and Clinical Analysis, Ghent University, Harelbekestraat 72, B-9000 Gent, Belgium*Corresponding author

In an in vitro study, less compound A was formed when a KOH-free carbon dioxide absorbent was used. To confirm this observation we used a lung model in which carbon dioxide was fed in at 160 ml min–1 and sampling gas was taken out for analysis at 200 ml min–1; ventilation aimed for a PE'CO2 of 5.4 kPa. The soda lime canister temperatures in the inflow and outflow ports (Tin and Tout) were recorded. In six runs of 240 min each, a standard soda lime, Sodasorb (Grace, Epernon, France) was used and in eight runs KOH-free Sofnolime (Molecular Products, Thaxted, UK) was used. Liquid sevoflurane was injected using a syringe pump to obtain 2.1% E'. Compound A was measured by capillary gas chromatography combined with mass spectrometry. Median (range) compound Ainsp increased to a maximum of 22.7 (7.9) ppm for Sodasorb and 33.1 (20) for Sofnolime at 60 min and decreased thereafter; the difference between groups was significant (P<0.05) at each time of analysis up to 240 min. The canister temperatures were similar in both groups and increased to ~40°C at 240 min. Contrary to expectation, compound A concentrations were greater with the KOH-free absorbent despite similar canister temperatures with both absorbents.

Br J Anaesth 2001; 86: 345–8


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Home page
 Anesth. Analg.Home page
M.-P. L. A. Bouche, L. F. M. Versichelen, M. M. R. F. Struys, J. F. P. Van Bocxlaer, A. P. De Leenheer, E. P. Mortier, and G. Rolly
No Compound A Formation with Superia(R) During Minimal-Flow Sevoflurane Anesthesia: A Comparison with Sofnolime(R)
Anesth. Analg., December 1, 2002; 95(6): 1680 - 1685.
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