British Journal of Anaesthesia, 2001, Vol. 86, No. 2 236-240
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia
Intrathecal sufentanil and morphine for post-thoracotomy pain relief
Service d’Anesthésie-Réanimation, Hôpital Tenon, Assistance Publique Hôpitaux de Paris, 4 rue de la Chine, F-75970 Paris cedex 20, France*Corresponding author
Presented in abstract form at the annual meeting of the European Society of Anaesthesiologists, Amsterdam, May 1999.
In this double-blind randomized study we compared a group of 15 patients undergoing thoracotomy who received a spinal injection of sufentanil 20 µg combined with morphine (200 µg) after induction of general anaesthesia with a control group of the same size. Post-operative pain was rated on a visual analogue scale (VAS) and a verbal rating scale at rest and with a VAS on coughing. In the recovery room, patients received titrated i.v. morphine until the VAS score was <30, and were followed by patient-controlled analgesia (PCA) for 72 h. The intrathecal sufentanil and morphine group had a lower intra-operative requirement for i.v. sufentanil and needed less i.v. morphine for titration in the recovery room. I.v. PCA morphine consumption and pain scores were lower in the active group than in the control group during the first 24 h. There were no differences after this time. Spirometric data (peak expiratory flow, forced vital capacity and forced expiratory volume in 1 s) were similar in the two groups. We conclude that the combination of intrathecal sufentanil and morphine produces analgesia of rapid onset and with a duration of 24 h.
Br J Anaesth 2001; 86: 236–40.
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