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British Journal of Anaesthesia, 2001, Vol. 86, No. 2 189-195
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Comparing the effects of stimulation and propofol infusion rate on implicit and explicit memory formation

J. Andrade1, L. Englert2, C. Harper2 and N. D. Edwards2

1Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TP, UK. 2University Department of Anaesthetics, Northern General Hospital, Sheffield S5 7AU, UK*Corresponding author

Doubt remains about the conditions under which learning persists despite anaesthesia. This study investigated the relative importance of dose of anaesthetic and stimulation for learning during propofol infusion before surgery. Thirty-six patients were randomly assigned to three groups. Group 1 received two word lists (category examples and nonsense words) during infusion of propofol to a target concentration of 2 µg ml–1. Groups 2 and 3 received the word lists during infusion of propofol 5 µg ml–1. Group 2 received nonsense words before tracheal intubation and category examples during intubation; Group 3 heard category examples before and nonsense words during intubation. Bispectral index was recorded as a measure of depth of sedation/anaesthesia. We assessed explicit memory on recovery using a structured interview and a recognition test. We assessed implicit memory using a category generation test and a preference rating task. To establish baseline, a control group of 12 patients completed the category generation test without receiving the category examples during anaesthesia. Overall, there was no evidence for learning during propofol infusion, though the category generation task showed a trend towards more implicit memory for words presented during intubation than during anaesthesia. We conclude that learning does not occur during anaesthesia without surgery.

Br J Anaesth 2001; 86: 189–95


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