British Journal of Anaesthesia, 2000, Vol. 85, No. 6 907-910
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia
Sex and oestrous cycle differences in visceromotor responses and vasopressin release in response to colonic distension in male and female rats anaesthetized with halothane
1Departments of Anaesthesia and Intensive Care and 2Medical Statistics and Evaluation, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK. 3Department of Physiology, St Thomas’ Hospital, King’s College School of Medicine, Lambeth Palace Road, London SE1 7EH, UK*Corresponding author
Presented in part to the Anaesthetic Research Society 1998 and published as an abstract in Br J Anaesth 1999; 82: 469–470P.
Visceromotor responses and vasopressin release before and after colonic visceral distension were compared between male (n=5 (n=4 for vasopressin)) and female rats and between females during the oestrous cycle (proestrus n=6, oestrus n=5, metestrus n=5, diestrus n=6) at a controlled depth of anaesthesia. Pre-stimulation vasopressin and blood pressures demonstrated oestrous cycle variability. The mean (SEM) colonic balloon pressure triggering visceromotor responses was significantly higher in males (64 (4) mm Hg) than females (41 (1) mm Hg), P=0.002 and within females, proestrus rats had the lowest thresholds, (29 (1) mm Hg, P<0.01). Post-stimulation, vasopressin concentrations increased significantly in all groups (males 1.34 (0.39) to 2.24 (0.74) pmol litre–1; females 1.54 (0.24) to 2.88 (0.58) pmol litre–1; P=0.002). Within groups statistically significant differences were measured in proestrus 2.06 (0.56) to 3.42 (1.12) and oestrus 1.16 (0.38) to 2.76 (0.60) pmol litre–1 (P<0.05). High vasopressin concentrations coupled with low-pressure stimulation during proestrus shows sex-hormone dependent integration of the neuroendocrine response to noxious visceral stimulation.
Br J Anaesth 2000; 85: 907–10
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Bradesi, V. Martinez, L. Lao, H. Larsson, and E. A. Mayer Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats Am J Physiol Gastrointest Liver Physiol, February 1, 2009; 296(2): G302 - G309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Shafford and J. C. Schadt Visceral pain decreases tolerance to blood loss in conscious female but not male rabbits Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R721 - R728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Perrin, L. A. Segall, V. L. Harbour, B. Woodside, and S. Amir The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle PNAS, April 4, 2006; 103(14): 5591 - 5596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ji, A. Z. Murphy, and R. J. Traub Estrogen Modulates the Visceromotor Reflex and Responses of Spinal Dorsal Horn Neurons to Colorectal Stimulation in the Rat J. Neurosci., May 1, 2003; 23(9): 3908 - 3915. [Abstract] [Full Text] [PDF]
|
|