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British Journal of Anaesthesia, 2000, Vol. 85, No. 6 898-900
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Prevention of postoperative nausea and vomiting by continuous infusion of subhypnotic propofol in female patients receiving intravenous patient-controlled analgesia

S. I. Kim1, T. H. Han2, H. Y. Kil3, J. S. Lee1 and S. C. Kim1

1Department of Anaesthesiology, Soonchunhyang University Hospital, 657 Hannam-Dong, Yongsan-Ku, Seoul, Korea. 2Department of Anaesthesiology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul, Korea. 3Department of Anaesthesiology, Hallym University Hospital, 445 Gil-Dong, Kangdong-Ku, Seoul, Korea*Corresponding author

In this prospective, randomized, double-blind, placebo-controlled study, the use of continuous subhypnotic propofol infusion as an antiemetic in fentanyl intravenous patient-controlled analgesia (i.v. PCA) was investigated during the first 24 h after surgery. One hundred female patients, ASA I–II, aged 20–71 yr, undergoing major gynaecological or orthopaedic surgery, were included. Either propofol 10 mg or placebo (1 ml of Intralipid) was given and one of the following five regimens was maintained for 24 h: propofol 5, 10, 15 or 20 µg kg–1 min–1 or Intralipid 1 ml h–1 as a placebo. Fentanyl i.v. PCA was started in the postanaesthesia care unit for postoperative analgesia. Significantly more of the patients given propofol 15 and 20 µg kg–1 min–1 experienced no nausea or vomiting compared with those given placebo (65% and 70% versus 25%; P<0.05). Patients given propofol 20 µg kg–1 min–1 reported more sedation than those in the other groups 4 h after surgery (P<0.05).

Br J Anaesth 2000; 85: 898–900


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