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British Journal of Anaesthesia, 2000, Vol. 85, No. 6 865-868
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Dexamethasone for prophylaxis of nausea and vomiting after epidural morphine for post-Caesarean section analgesia: comparison of droperidol and saline

J. I. Tzeng1,2, J. J. Wang2,4, S. T. Ho2, C. S. Tang1, Y. C. Liu3 and S. C. Lee3

1Department of Anaesthesiology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. 2Department of Anaesthesiologyand 3Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan. 4Department of Anaesthesiology, Chi-Mei Medical Center, Tainan, Taiwan*Corresponding author: Department of Surgery, Tri-Service General Hospital/National Defense Medical Center, Rm 8113, No. 161, Sec. 6, Minchuan E. Rd., Taipei, Taiwan

We have evaluated the prophylactic effect of i.v. dexamethasone 8 mg in preventing nausea and vomiting during epidural morphine for post-Caesarean section analgesia. Droperidol 1.25 mg and saline served as the control. We studied 120 parturients (n=40 in each group) receiving epidural morphine for post-Caesarean section analgesia, in a randomized, double-blind, placebo-controlled study. All parturients received epidural morphine 3 mg. Both dexamethasone and droperidol significantly decreased the total incidence of nausea and vomiting compared with saline, with incidences of 18, 21 and 51% for the three treatments respectively (P<0.01 and P<0.05 respectively). Parturients who received droperidol reported a more frequent incidence of restlessness (16%) than those who received dexamethasone (P<0.05).

Br J Anaesth 2000; 85: 865–8


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