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British Journal of Anaesthesia, 2000, Vol. 85, No. 6 861-864
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Pre-operative oral erythromycin reduces residual gastric volume and acidity

T. Asai, K. Murao and K. Shingu

Department of Anesthesiology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8507, Japan*Corresponding author

We investigated whether low-dose erythromycin (200 mg) given as an oral premedicant altered the residual gastric volume and its acidity in fasted patients at induction of anaesthesia in a single-blinded study. Sixty patients were allocated randomly to receive either an erythromycin tablet (200 mg) or nothing with 10 ml water 3 h before induction of anaesthesia, and another 60 patients 1 h before induction of anaesthesia. Oral erythromycin significantly reduced residual gastric volume when it was given approximately 3 h (P<0.05; 95% CI for median difference: 0.1–17 ml) or 1 h (P<0.0005; 95% CI for median difference: 6–24 ml) before induction of anaesthesia. Erythromycin significantly reduced gastric acidity when it was given 1 h before induction of anaesthesia (P<0.02; 95% CI for median pH difference: 0.1–1.7). In contrast, when given 3 h before induction of anaesthesia, erythromycin did not significantly alter acidity.

Br J Anaesth 2000; 85: 861–4


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