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British Journal of Anaesthesia, 2000, Vol. 85, No. 5 712-716
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Xenon does not induce contracture in human malignant hyperthermia muscle{dagger}

C. P. Baur1,2,*, W. Klingler1,2, K. Jurkat-Rott1, G. Froeba2, E. Schoch1, T. Marx2, M. Georgieff2 and F. Lehmann-Horn1

1Department of Applied Physiology, 2Department of Anaesthesiology, University of Ulm, Ulm, Germany

{dagger}Presented in part at the 10th European Congress of Anaesthesiology, Frankfurt/Main, Germany, June 30–July 4, 1998.

Xenon has many characteristics of an ideal anaesthetic agent. It is not known whether xenon is a safe alternative to the potent inhalational anaesthetics in patients susceptible to malignant hyperthermia (MH). We investigated the effect of xenon, halothane and caffeine on muscle specimens of 31 individuals, referred to the MH Unit of the University of Ulm, and performed genetic epidemiology. Thirteen individuals were classified as MH susceptible and 18 as MH negative. Xenon 70% did not cause an increase in baseline tension of any MH-susceptible muscle specimen in contrast to halothane and caffeine. The evoked twitch response increased transiently in MH-susceptible and normal specimens indicating a mechanism independent of MH susceptibility. These results suggest that xenon, in concentrations up to 70% may be a safe anaesthetic for MH-susceptible patients.

Br J Anaesth 2000; 85: 712–16

* Corresponding author: Universitätsklinik für Anaesthesiologie, Postfach 3880, D-89070 Ulm, Germany


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