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British Journal of Anaesthesia, 2000, Vol. 85, No. 4 623-625
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Comparison of intubating conditions following propofol and succinylcholine with propofol and remifentanil 2 µg kg–1 or 4 µg kg–1

I. A. McNeil, B. Culbert and I. Russell

Department of Anaesthesia, Hull Royal Infirmary, Anlaby Road, Hull HU3 2JZ, UK

We evaluated the intubating conditions, haemodynamic responses and duration of apnoea in 60 healthy adult patients after propofol 2 mg kg–1 combined with either a bolus of remifentanil 2 µg kg–1 or 4 µg kg–1, or succinylcholine 1 mg kg–1. Patients intubated following remifentanil showed dose-dependent intubating conditions, similar at 4 µg kg–1 to the conditions produced with succinylcholine. Post-induction mean arterial pressure decreased from baseline values by 21% (P<0.0001), 28% (P<0.0001) and 8% (P>0.05) in the remifentanil 2 µg kg–1, remifentanil 4 µg kg–1 and succinylcholine 1 mg kg–1 groups, respectively. The mean (SD) duration of apnoea following induction was 9.3 (2.6) min and 12.8 (2.9) min in the remifentanil 2 µg kg–1 and 4 µg kg–1 groups, and 6.0 (0.9) min in the succinylcholine group (P<0.001 between groups).

Br J Anaesth 2000; 85: 623--5


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