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British Journal of Anaesthesia, 2000, Vol. 85, No. 4 506-511
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Ropivacaine pharmacokinetics after caudal block in 1–8 year old children

P. A. Lönnqvist1,*, P. Westrin2, B. A. Larsson1, G. L. Olsson1, A. Lybeck3, G. Huledal3 and M. Bielenstein3

1Department of Paediatric Anaesthesia and Intensive Care, KS/Astrid Lindgren’s Children’s Hospital, Stockholm, Sweden. 2Department of Anaesthesia and Intensive Care, Lund University Hospital, Lund, Sweden. 3AstraZeneca R&D, Södertälje, Sweden

We studied the pharmacokinetics after caudal block of ropivacaine (2 mg ml–1, 1 ml kg–1) performed in 20 children aged 1–8 yr undergoing subumbilical surgery, in this open, non- comparative, multicentre study. Venous blood samples were collected up to 12–36 h. The mean (SD) peak plasma concentration, 0.47 (0.16) mg litre–1, was achieved after 12–249 min. The free fraction was 5% and the highest individual peak plasma concentration of free ropivacaine was 0.04 mg litre–1. Clearance was 7.4 (1.9) ml min–1 kg–1 and the terminal half-life 3.2 (0.8) h. Thus, the free plasma concentrations of ropivacaine were well below those associated with toxic symptoms in adults and the capacity to eliminate ropivacaine seems to be well developed in this age group. In this open study of 20 patients, ropivacaine was well tolerated and provided satisfactory postoperative pain relief without observable motor block.

Br J Anaesth 2000; 85: 506–11

* Corresponding author: Paediatric Anaesthesia and Intensive Care, KS/Astrid Lindgren’s Children’s Hospital, SE-171 76 Stockholm, Sweden


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