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British Journal of Anaesthesia, 2000, Vol. 85, No. 3 471-481
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Repetitive synchronized cyclical oscillations of multisystem parameters subsequent to high-dose thiopental therapy for status epilepticus secondary to herpes encephalitis

I. R. Ghosh1,2,*, R. M. Langford2, K. Nieminen3, A. Kari3 and J. Takala3

1Department of Clinical Neurophysiology and 2Anaesthetic Laboratory, St Bartholomew’s Hospital, London, UK. 3Critical Care Research Program, Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland

We report a case of status epilepticus secondary to herpes encephalitis, treated with thiopental infusion and mechanical ventilation. The computerized storage and analysis of physiological data led to the detection of repetitive synchronized cyclical oscillations of arterial pressure, heart rate, EEG parameters, peripheral temperature and core temperature. Arterial pressure oscillations have been described in patients who are severely systemically unwell; cardiovascular and brain electrical activity may also oscillate in the presence of raised intracranial pressure. In contrast, this patient had no features of severe systemic illness or of raised intracranial pressure. Our hypothesis is that high-dose thiopental may have been a cause of our findings by producing autonomic dysfunction.

Br J Anaesth 2000; 85: 471–3

* Corresponding author: Anaesthetic Laboratory, St Bartholomew’s Hospital, 38 Little Britain, London EC1A 7BE, UK


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[Abstract] [PDF]


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