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British Journal of Anaesthesia, 2000, Vol. 85, No. 3 440-445
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Effects of sevoflurane on hypoxic pulmonary vasoconstriction in anaesthetized piglets

F. Kerbaul1, M. Bellezza1, C. Guidon1, L. Roussel2, M. Imbert2, J. P. Carpentier2 and J. P. Auffray3

1Département d’Anesthésie–Réanimation Adulte, Groupe Hospitalier de La Timone, F-13385 Marseille Cedex 05, France. 2Département d’Anesthésie–Réanimation, Hôpital d’Instruction des Armées Laveran, F-13998 Marseille, France. 3Département d’Anesthésie–Réanimation, Hôpital Sainte Marguerite, Marseille Cedex 09, France.*Corresponding author

In vitro, halogenated agents reduce the pulmonary vasoconstrictor response to alveolar hypoxia in isolated perfused lungs. However, studies in intact animals have been less convincing. The aim of the present study was to assess the effect of sevoflurane on hypoxic pulmonary vasoconstriction (HPV) in anaesthetized piglets using the pressure/cardiac index relationship (P/Q).Ten large white piglets were anaesthetized and mechanically ventilated, alternately in hyperoxia (FIO2=0.4) and hypoxia (FIO2=0.12). Multipoint plots of pulmonary arterial pressure (PAP) or differences between PAP and left atrial pressure (LAP) against Q were generated by gradual inflation of a balloon introduced into the inferior vena cava. P/Q relationships were established in hyperoxia and hypoxia at baseline, and then with sevoflurane. In hypoxia, pressure gradients (PAP – LAP) increased at every level of Q, thus demonstrating active pulmonary vasoconstriction. Sevoflurane at 1 MAC did not affect these P/Q relationships in hyperoxia or hypoxia as compared with baseline. Sevoflurane at a clinically relevant concentration (1 MAC) has no significant effect on HPV in anaesthetized piglets.

Br J Anaesth 2000; 85: 440–5


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