Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Fu, W.
Right arrow Articles by Greenberg, C. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fu, W.
Right arrow Articles by Greenberg, C. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2000, Vol. 85, No. 2 302-305
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Brief Communication

Rapacuronium recovery characteristics and infusion requirements during inhalation versus propofol-based anaesthesia

W. Fu1, K. W. Klein1, P. F. White1, J. W. Chiu1, H. J. M. Lemmens2, D. G. Whalley3, D. R. Drover2 and C. P. Greenberg4

1Department of Anesthesiology, University of Texas Southwestern Medical Center, Dallas, TX, USA, 2Stanford University, Stanford, CA, USA, 3Cleveland Clinic Foundation, Cleveland, OH, USA, and 4Columbia University, New York, NY, USA*Corresponding author

Abstract

We examined the effect of four maintenance anaesthetics on the neuromuscular blocking activity and spontaneous recovery characteristics after a short-term infusion of rapacuronium. Eighty ASA I–III adult patients undergoing elective surgery were studied at four centres. Anaesthesia was induced with propofol 1.5–2.5 mg kg–1 and fentanyl 1–2 µg kg–1, followed by a bolus of rapacuronium 1.5 mg kg–1. The patients were randomized to receive either desflurane (2–4% end-tidal, ET), sevoflurane (0.75–1.5% ET), isoflurane (0.4–0.8% ET), or a propofol infusion (75–150 µg kg–1 min–1) for maintenance of anaesthesia in combination with nitrous oxide (60–70%) in oxygen. When the first twitch (T1) of a train-of-four stimulus (using the TOF Guard® accelerometer) returned to 5%, an infusion of rapacuronium was started at 3 mg kg–1 h–1 and adjusted to maintain T1/T0 at 10%. The duration of infusion lasted between 45 and 60 min, and the average infusion rates of rapacuronium were similar in all groups, ranging from 1.6 to 2.5 mg kg–1 h–1. There were no significant differences among the groups in the times for T1/T0 to return to 25%, 75% or 90%, or for T4/T1 to return to 70% and 80% upon discontinuation of the infusion. When potent inhalation anaesthetics are used in clinically relevant concentrations for maintenance of anaesthesia, the neuromuscular recovery profile of rapacuronium administered as a variable-rate infusion for up to 1 h is similar to that found with a propofol-based anaesthetic technique.

Br J Anaesth 2000; 85: 302–5


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
P. F. White
Editorial II: Rapacuronium: why did it fail as a replacement for succinylcholine?
Br. J. Anaesth., February 1, 2002; 88(2): 163 - 165.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.