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British Journal of Anaesthesia, 2000, Vol. 85, No. 2 281-286
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Effects of protein binding on the placental transfer of propofol in the human dually perfused cotyledon in vitro

Y.-L. He*, S. Tsujimoto, M. Tanimoto, R. Okutani, K. Murakawa and C. Tashiro

Department of Anaesthesiology, Hyogo College of Medicine, 1–1 Mukogawa-cho, Nishinomiya City 663-8501, Japan

The placental transfer of propofol was investigated using the in vitro dually perfused cotyledon model of the human placenta, and the effects of protein binding in the foetal perfusate were examined. Both maternal and foetal circulations were perfused in a single-pass mode and >30 min of stabilization was allowed before adding propofol and antipyrine to the maternal perfusate. The placental clearances of propofol were significantly increased by the augmented albumin concentrations in the foetal perfusate (1.68 (SD 0.68), 3.08 (1.55), 4.79 (1.76), 5.75 (1.89) and 7.03 (1.46) ml h–1 g–1 at the albumin concentrations of 4.4, 11, 22, 33 and 44 g litre–1, respectively). Although the total propofol concentration in the foetal vein increased significantly with increasing albumin concentration, the concentration of free propofol remained unchanged. These results indicate that binding to foetal albumin is a determining feature in the control of the placental transfer of propofol, and that the pharmacological effects of propofol on the foetus can be expected to be fairly constant and predictable from the maternal propofol concentration.

Br J Anaesth 2000; 84: 281–6

* Corresponding author


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This article has been cited by other articles:


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 Anesth. Analg.Home page
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The Influences of Maternal Albumin Concentrations on the Placental Transfer of Propofol in Human Dually Perfused Cotyledon In Vitro
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Y.-L. He, H. Seno, S. Tsujimoto, and C. Tashiro
The Effects of Uterine and Umbilical Blood Flows on the Transfer of Propofol Across the Human Placenta During In Vitro Perfusion
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