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British Journal of Anaesthesia, 2000, Vol. 85, No. 2 211-216
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Influence of tramadol on the ventilatory response to hypoxia in humans

P. M. Warren1,*, J. H. Taylor2, K. E. Nicholson2, P. K. Wraith3 and G. B. Drummond4

1Respiratory Medicine Unit, Department of Medical and Radiological Science, University of Edinburgh, Royal Infirmary, Edinburgh, 2Department of Pharmacology, University of Edinburgh, 3Department of Medical Physics, Western General Hospital, Edinburgh and 4Department of Anaesthetics, University of Edinburgh, Royal Infirmary, Edinburgh, UK

We studied the effect of tramadol on the ventilatory response to 7 min acute isocapnic hypoxia (SpO2 85.1 (SD 0.4)%) during steady mild hypercapnia (PE'co2 0.7 kPa above normoxic baseline) in 14 healthy volunteers (seven male). The acute hypoxic response was measured before and 1 h after oral placebo or tramadol (100 mg). After tramadol, ventilation during mild hypercapnia (mean 11.28 litres min–1) was significantly less (P<0.05) than during placebo baseline (13.93 litres min–1), tramadol baseline (14.63 litres min–1), or after placebo (14.95 litres min–1), confirming that tramadol has a small depressive effect on the hypercapnic ventilatory response. There was no significant difference in the hypoxic ventilation/SpO2 response (l min–1 %–1) measured during the placebo baseline (0.99), placebo (1.18), tramadol baseline (0.78) or tramadol (0.68) runs. These data suggest that tramadol does not depress the hypoxic ventilatory response.

Br J Anaesth 2000; 85: 211–6

* Correspondingauthor


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