British Journal of Anaesthesia, Vol 82, Issue 4 596-602, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
C. Eintrei, L. Sokoloff and C. B. Smith
The effects of diazepam, which acts at GABAA receptors to enhance the
effects of GABA, and ketamine, a non-competitive N-methyl-D-aspartate
receptor antagonist, on local rates of cerebral glucose utilization
(ICMRglc) were examined in unrestrained rats. Four groups were studied:
vehicle-injected controls; and ketamine-treated, diazepam-treated and
combined ketamine- and diazepam-treated animals. Ketamine alone produced a
heterogeneous pattern of changes in ICMRglc (e.g. significant increases in
the corpus callosum, olfactory tubercle and the entire Papez circuit, in
addition to other limbic areas, and significant decreases in lateral
habenula and some components of the auditory system). Diazepam alone
statistically significantly decreased ICMRglc in the brain as a whole and
in most areas of the cerebral cortex, thalamus and limbic system. The most
remarkable effects of the two drugs administered together on ICMRglc
occurred in the limbic system where the dramatic increases observed with
ketamine alone were prevented by treatment with diazepam.
LABORATORY INVESTIGATIONS
Effects of diazepam and ketamine administered individually or in combination on regional rates of glucose utilization in rat brain
Department of Anaesthesia, University Hospital, S-581 85 Linkoping, Sweden; Laboratory of Cerebral Metabolism, National Institute of Mental Health, US Public Health Service, Department of Health and Human Services, Bethesda, MD 20892, USA
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