British Journal of Anaesthesia, Vol 82, Issue 1 90-96, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
K. Y. Yoo, S. Y. Yang, J. Lee, W. M. Im, C. Y. Jeong, S. S. Chung and S. H. Kwak
We have investigated the effects of propofol on recovery of regional
mechanical and coronary endothelial function and on lipid peroxidation in
post-ischaemic myocardium in dogs. The animals were assessed for 180 min
during reperfusion after 15-min of occlusion of the left anterior
descending coronary artery (LAD). They were treated with intracoronary
(i.c.) propofol 5 or 20 micrograms/ml of coronary flow or vehicle (control
group) for 60 min, beginning 30 min before LAD occlusion. Propofol
significantly enhanced recovery of regional contractile function (70% and
81% of baseline segment shortening in the propofol 5 and 20 micrograms ml-1
groups, respectively, compared with 51% in controls at 3 h of reperfusion).
However, LAD flow responses to i.c. acetylcholine were similarly attenuated
regardless of treatment with propofol throughout reperfusion. The increase
in malondialdehyde induced by ischaemia-reperfusion was significantly
suppressed by both doses of propofol. These results demonstrated that in
vivo, propofol ameliorated dysfunction of the myocardium but not of the
coronary endothelium resulting from brief ischaemia and reperfusion; the
protection may be related, at least in part, to its ability to reduce lipid
peroxidation.
LABORATORY INVESTIGATIONS
Intracoronary propofol attenuates myocardial but not coronary endothelial dysfunction after brief ischaemia and reperfusion in dogs
Department of Anaesthesia, Chonnam University Medical School, 8 Hak-dong, Kwangju 501-190, Korea; Department of Biochemistry, Chonnam University Medical School, 8 Hak-dong, Kwangju 501-190, Korea; Department of Physiology, Chonnam University Medical School, 8 Hak-dong, Kwangju 501-190, Korea;
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