British Journal of Anaesthesia, Vol 82, Issue 1 104-109, Copyright © 1999 by The Board of Management and Trustees of the British Journal of Anaesthesia
O. Bastien, V. Piriou, A. Aouifi, R. Evans and J. J. Lehot
Decreased gut perfusion has been reported during cardiopulmonary bypass
(CPB). Studies of treatments to avoid splanchnic ischaemia during CPB have
given conflicting results. We studied 12 rabbits during mild hypothermic
non-pulsatile CPB. Tissue blood flow in three different splanchnic areas
(gastric, jejunum and ileum) was measured by laser Doppler velocimetry
(LDV) before CPB (T0), after steady state (T1), after administration of
dopexamine 2 micrograms kg-1 min-1 (T2) and 4 micrograms kg-1 min-1 (T3),
and after return to baseline (T4). Splanchnic blood flow decreased during
CPB. Dopexamine increased significantly jejunum LDV (100% at T1 to mean 271
(SD 210)% at T2) and ileum LDV (100% at T1 to 187 (112)% at T2). Gastric
LDV was not altered by infusion of dopexamine during CPB. This could partly
explain the conflicting results on the value of gastric tonometry as an
index of splanchnic injury.
LABORATORY INVESTIGATIONS
Effects of dopexamine on blood flow in multiple splanchnic sites measured by laser Doppler velocimetry in rabbits undergoing cardiopulmonary bypass
Universite Claude Bernard, EA 1896, 8 Avenue Rockfeller, 69 008 Lyon, France; Present addressess: Service d'Anesthesie Reanimation, Hopital Cardiologique et Pneumologique L. Pradel, HCL, EA 1896, Lyon, France. Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford OX2 6HE, UK
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