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British Journal of Anaesthesia, Vol 81, Issue 4 553-555, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Effects of dantrolene on the diaphragm muscle of the normal and myopathic hamster

O. Langeron, C. Coirault, S. Fratea, G. Orliaguet, P. Coriat and B. Riou
Laboratory of Anaesthesiology, Department of Anaesthesiology and Critical Care, Centre Hospitalo-Universitaire (CHU) Pitie-Salpetriere, Paris VI University, Paris, France; INSERM U451, LOA-ENSTA-Ecole Polytechnique, Palaiseau and Service de Physiologie Cardiovasculaire et Respiratoire, CHU Bicetre, Le Kremlin-Bicetre, France; Department of Anaesthesiology and Critical Care, CHU Necker-Enfants Malades, Paris, France

Dantrolene is the only known effective treatment for malignant hyperthermia. However, its effects on the myopathic diaphragm remain unknown. The effects of dantrolene 10(-8) to 10(-4) mol litre-1 on diaphragm muscle strips in normal (n = 12) and myopathic hamsters (n = 13) were investigated in vitro in response to tetanic stimulation. We studied contraction under isotonic and isometric conditions. Data are presented as mean (SD) percent of baseline. Dantrolene induced a negative inotropic effect in normal and myopathic hamsters but no significant difference was observed between groups (active force at 10(- 4) mol litre-1; 34 (7) vs 32 (11)%; ns). We conclude that dantrolene induced a comparable negative inotropic effect on diaphragm muscle in normal and myopathic hamsters.
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