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British Journal of Anaesthesia, Vol 81, Issue 3 444-448, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Antibacterial activity of lidocaine in mixtures with Diprivan

R. J. Gajraj, M. J. Hodson, J. A. Gillespie, GNC. Kenny and N. B. Scott
Department of Anaesthesia, The General Infirmary at Leeds, Leeds; Department of Anaesthesia, Southern General Hospital, Glasgow; Department of Anaesthesia, Victoria Infirmary, Glasgow; University Department of Anaesthesia, Royal Infirmary, Glasgow; Department of Anaesthesia, HCI International Medical Centre, Beardmore Street, Clydebank G81 4HX

We have studied the antibacterial activity of different concentrations of 0.005-2% lidocaine (lignocaine) in mixtures with Diprivan (propofol), against micro-organisms commonly implicated in sepsis as a result of extrinsically contaminated Diprivan. Bacterial colony counts were reduced progressively with increasing concentrations of lidocaine. Bacteriostatic and bactericidal concentrations of lidocaine were 0.2- 2%. Lidocaine 2% was not bactericidal for one of the seven organisms tested. By inhibiting bacterial replication, lidocaine, when added to Diprivan to reduce pain on injection, may possibly reduce the harmful consequences if extrinsic contamination occurs.
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