British Journal of Anaesthesia, Vol 80, Issue 5 628-633, Copyright © 1998 by The Board of Management and Trustees of the British Journal of Anaesthesia
J. Utsumi, T. Adachi, J. Kurata, Y. Miyazaki, M. Shibata, M. Murakawa, T. Arai and K. Mori
We have compared the effects of xenon and nitrous oxide on central nervous
system (CNS) electrical activity during sevoflurane anaesthesia in cats by
recording the electroencephalogram (EEG), multi-unit activity of the
midbrain reticular formation (R-MUA) and somatosensory evoked potentials
(SEP). Basal anaesthesia with 2% and 5% sevoflurane was used. With 2%
sevoflurane, 70% xenon initially produced rhythmic slow waves which were
followed by bursts of high-amplitude sharp waves interrupted by low
amplitude slow waves on the EEG. Xenon induced an initial increase,
followed by a decrease in R-MUA. Nitrous oxide 70% decreased the amplitude
of the EEG activity which was associated with an increase in R-MUA. Xenon
suppressed the amplitude of both the initial positive and negative
deflections of the SEP to a greater extent than nitrous oxide. With 5%
sevoflurane anaesthesia, both anaesthetics increased the frequency of
spikes on the EEG and facilitated R-MUA. These findings indicate that xenon
has a stimulatory action on CNS background activity and a suppressive
action on CNS reactive capability which is more potent than that of nitrous
oxide.
LABORATORY INVESTIGATIONS
Effect of xenon on central nervous system electrical activity during sevoflurane anaesthesia in cats: comparison with nitrous oxide
Department of Anaesthesia, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-01, Japan
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