British Journal of Anaesthesia, Vol 79, Issue 3 280-284, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia
S. T. Paris, M. Cafferkey, M. Tarling, P. Hancock, P. M. Yate and P. J. Flynn
In a prospective, randomized, double-blind clinical study, we have studied
100 children, aged 2-12 yr, to compare halothane and sevoflurane in
outpatient dental anaesthesia. All patients were unpremedicated and
received inhalation induction using nitrous oxide in oxygen supplemented
with either halothane (maximum inspired concentration 5%) or sevoflurane
(maximum inspired concentration 8%). Time to loss of the eyelash reflex was
more rapid using sevoflurane although time to adequate anaesthesia (to
allow insertion of a mouth prop) was slower in the sevoflurane group. The
incidence of cardiac arrhythmia was higher during halothane (62%) than
during sevoflurane anaesthesia (28%) (P < 0.005) and the arrhythmias
were more often ventricular in origin. The two agents were comparable in
terms of ease of use and quality of anaesthesia, and times to eye opening
and satisfying discharge criteria were similar. We conclude that
sevoflurane has qualities that have made halothane the most used inhalation
agent for children, and that it is superior to halothane in dental
outpatients where cardiac arrhythmias are a particular problem.
CLINICAL INVESTIGATIONS
Comparison of sevoflurane and halothane for outpatient dental anaesthesia in children
Anaesthetics Unit, Royal Hospitals NHS Trust, Whitechapel, London E1 1BB; Department of Medicine, Royal Hospitals NHS Trust, Whitechapel, London E1 1BB; Anaesthetics Department, Royal Hospitals NHS Trust, Whitechapel, London E1 1BB
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