Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (16)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Inomata, S.
Right arrow Articles by Kihara, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Inomata, S.
Right arrow Articles by Kihara, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, Vol 78, Issue 6 754-756, Copyright © 1997 by The Board of Management and Trustees of the British Journal of Anaesthesia

SHORT COMMUNICATIONS

"Best" PEEP during one-lung ventilation

S. Inomata, T. Nishikawa, S. Saito and S. Kihara
Department of Anaesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki 305, Japan

Eight patients were studied under general anaesthesia for elective pulmonary lobectomy to see if intrinsic positive end-expired pressure (PEEPi) would appear or increase in the dependent lung during one-lung ventilation (OLV) or if application of external PEEP equal to individually measured PEEPi would produce better arterial oxygenation, haemodynamic state and oxygen delivery than either zero PEEP (ZEEP) or an external PEEP 5 cm H2O greater than PEEPi. Patients were non-obese, without obstructive airways disease, aged 53-76 yr and ASA < III. They received standardized anaesthesia with fentanyl, 50% nitrous oxide in oxygen and isoflurane; monitoring included radial and fibreoptic pulmonary arterial catheters and intermittent positive pressure ventilation with a tidal volume of 8 ml kg-1, 16 bpm, and an I:E ratio of 1:2. PEEPi was measured during two-lung ventilation (TLV) and OLV, using rapid airway occlusion at end-expiration. There was no PEEPi during TLV, but 2-6 mm Hg of PEEPi appeared during OLV. Applying external PEEP equal to individually measured PEEPi reduced venous admixture and increased PaO2 without a decrease in cardiac index (thus increasing oxygen delivery) compared with ZEEP, but the improvement in pulmonary gas exchange was lost and an additional penalty of reduced cardiac output was imposed when external PEEP was increased to 5 mm Hg above PEEPi.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
P. Michelet, A. Roch, D. Brousse, X.-B. D'Journo, F. Bregeon, D. Lambert, G. Perrin, L. Papazian, P. Thomas, J.-P. Carpentier, et al.
Effects of PEEP on oxygenation and respiratory mechanics during one-lung ventilation
Br. J. Anaesth., August 1, 2005; 95(2): 267 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Gama de Abreu, M. Heintz, A. Heller, R. Szechenyi, D. M. Albrecht, and T. Koch
One-Lung Ventilation with High Tidal Volumes and Zero Positive End-Expiratory Pressure Is Injurious in the Isolated Rabbit Lung Model
Anesth. Analg., January 1, 2003; 96(1): 220 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
K.M. Sherry
Editorial II: How can we improve the outcome of oesophagectomy?
Br. J. Anaesth., May 1, 2001; 86(5): 611 - 613.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.