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British Journal of Anaesthesia, Vol 76, Issue 3 428-434, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Effects of carbon dioxide embolism with nitrous oxide in the inspired gas in piglets

J. B. Nyarwaya, S. Pierre, J. X. Mazoit, V. Umbrain, M. Romain, K. Samii and A. d'Hollander
Experimental Laboratory of the Department of Anaesthesiology, CUB Erasme, 808 Route de Lennik, 1070 Brussels, Belgium

We have compared cardiorespiratory variables in anaesthetized piglets whose lungs were ventilated with oxygen in nitrous oxide (N2O group) or nitrogen (N group) after right ventricular carbon dioxide boluses (0.5 or 1 ml kg-1; n = 12) or slow graded injections (n = 6). Boluses affected all variables studied significantly (P < 0.05) except mean systolic arterial pressure. Significant changes in PE'CO2 (P = 0.012) and PaO2 (P = 0.048) values were observed in the N2O group. Changes in PaCO2 were related to volumes of injected carbon dioxide (P = 0.044). Boluses of 1.0 ml kg-1 induced severe circulatory collapse in two piglets in the N2O group. Slow embolization altered respiratory variables significantly (P < 0.001)). PaO2 decreased significantly in the N2O group (P < 0.0001). Mean pulmonary arterial pressure increased significantly over time (P = 0.001) and lasted longer in the N2O group (P < 0.05). Volumes and time required to induce a 50% increase in mean pulmonary arterial pressure differed significantly between groups (P < 0.05). We conclude that nitrous oxide worsened the effects of rapid and slow carbon dioxide emboli on cardiopulmonary variables. Rapid carbon dioxide embolism altered respiratory and haemodynamic variables, while slow carbon dioxide embolism changed only respiratory variables.
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 Anesth. Analg.Home page
A. Ferrando, I. Garutti, C. Pulido, S. Diaz-Ruano, E. G. De Lucas, E. V. Nishanian, and N. G. Goudsouzian
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Anesth. Analg., January 1, 1999; 88(1): 227 - 228.
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