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British Journal of Anaesthesia, Vol 76, Issue 3 415-418, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia


CLINICAL INVESTIGATIONS

Effect of tramadol on depth of anaesthesia

J. F. Coetzee, J. S. Maritz and J. C. du Toit
Department of Anesthesiology, University of Stellenbosch/Tygerberg Hospital, PO Box 19063, 7505 Tygerberg, Republic of South Africa; University of Witwatersrand, Department of Statistics, University of Stellenbosch/Tygerberg Hospital, PO Box 19063, 7505 Tygerberg, Republic of South Africa; Department of Anesthesiology, Tygerberg Hospital, Private bag, 7505 Tygerberg, Rupublic of South Africa

We have studied 51 patients who were anaesthetized with propofol and suxamethonium followed by 0.7% isoflurane and 66% nitrous oxide in oxygen to see if tramadol caused lightening of anaesthesia. A two- channel EEG was recorded and music was played via headphones. Two groups received tramadol 200 and 100 mg i.v. and the third group received saline. Tramadol caused significant, dose-dependent activation of the EEG, evidenced by increased frequencies and decreased amplitudes, but these changes were small and probably unimportant. Derived EEG variables did not approach values known to be associated with near-awakening during isoflurane anaesthesia. No patient moved on skin incision and there were no incidences of free recall.
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