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British Journal of Anaesthesia, Vol 76, Issue 1 77-80, Copyright © 1996 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Prilocaine 3% is superior to a mixture of bupivacaine and lignocaine for peribulbar anaesthesia

U. R. Dopfmer, D. G. Maloney, P. A. Gaynor, RMH. Ratcliffe and S. Dopfmer
Department of Anaesthesia, East Surrey Hospital, Three Arch Road, Redhill, Surrey RH1 5RH; Institut fur Medizinische Statistik, Universitatsklinikum Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany

We have compared motor block of the extraocular muscles produced by injections of 3% prilocaine and a mixture of equal parts of 2% lignocaine and 0.75% bupivacaine into the medial compartment of the orbit. A volume of 8 ml was used initially, and a vasoconstrictor and hyaluronidase were added to both solutions. Ninety patients undergoing cataract surgery were allocated randomly to one of two groups in double- blind study. Eight minutes after block insertion, the median ocular movement score in the prilocaine group was 1 and in the lignocaine- bupivacaine group 3. This difference was statistically significant (P = 0.016). Twenty of the patients who received prilocaine and 29 of the patients who received the lignocaine-bupivacaine mixture required an additional inferotemporal injection. This difference was not statistically significant (P = 0.094).
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