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British Journal of Anaesthesia, Vol 75, Issue 3 286-288, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia

CLINICAL INVESTIGATIONS

Peritonsillar infiltration with low-dose tenoxicam after tonsillectomy

K. E. Knudsen, S. Brofeldt, S. Mikkelsen, M. Bille, J. Brennum and J. B. Dahl
Department of Anaesthesiology, Bispebjerg University Hospital, DK-2400 Bispebjerg, Copenhagen, Denmark; Department of Oto-Laryngology, Bispebjerg University Hospital, DK-2400 Bispebjerg, Copenhagen, Denmark; Department of Anaesthesiology, Glostrup University Hospital, DK-2600 Glostrup, Copenhagen, Denmark

We have compared the effect of peritonsillar infiltration with tenoxicam 5 mg and placebo on postoperative pain after tonsillectomy. Fifty patients undergoing bilateral elective tonsillectomy under general anaesthesia were allocated randomly to receive peritonsillar infiltration with tenoxicam 5 mg in 8 ml of normal saline (4 ml per tonsil) or normal saline only, before tracheal extubation. Median time to first request for morphine (30 min in each group, P = 0.83), cumulative morphine requirements from 0 to 2 h after surgery (two and one doses, P = 0.50), and from 2 to 24 h after surgery (one dose in each group, P = 0.17) were similar. There were no significant differences between groups in VAS scores at rest or when drinking 100 ml of water at any time. The power of detecting a reduction in VAS scores of 20 mm was 90% at the 5% significance level.
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