British Journal of Anaesthesia, Vol 75, Issue 3 282-285, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia
R. A. Lawson, N. G. Smart, A. C. Gudgeon and N. S. Morton
We have evaluated the efficacy and safety of a preparation of 4%
amethocaine gel in alleviating the pain of venous cannulation in children.
In an initial open study of 148 children, clinically acceptable anaesthesia
was achieved in 92% of cases. The preparation was then compared with 5%
EMLA cream in a single-blind study in 94 patients using an application time
of 40 min. We found clinically acceptable conditions in 85% of patients
receiving amethocaine gel compared with 66% in the EMLA group. There were
no significant adverse effects noted in each group, although 37% of those
children treated with amethocaine gel showed localized erythema at the
application site. The results suggest that amethocaine gel has greater
efficacy and a faster onset time than EMLA cream when used for this purpose
in children.
CLINICAL INVESTIGATIONS
Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children
Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill NHS Trust, Glasgow B3 8SJ; Smith and Nephew Pharmaceuticals Ltd, Bampton Road, Harold Hill, Romford RM3 8SL
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