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British Journal of Anaesthesia, Vol 75, Issue 1 61-65, Copyright © 1995 by The Board of Management and Trustees of the British Journal of Anaesthesia

LABORATORY INVESTIGATIONS

Glutamate uptake is not a major target site for anaesthetic agents

B. Nicol, D. J. Rowbotham and D. G. Lambert
University Department of Anaesthesia, Leicester Royal Infirmary, Leicester LE1 5WW

We have examined the effects of thiopentone, propofol and ketamine 3- 300 mumol litre-1, 3.6%, 2.4 rat MAC of isoflurane, 3.0%, 2.4 rat MAC of halothane and morphine 0.1-10 mumol litre-1 on uptake of [3H]glutamate into rat cerebrocortical and cerebellar synaptosomes. Corticol and cerebellar synaptosomes took up [3H]glutamate in a time-, concentration-, Na(+)-dependent and L-transpyrrolidine-2,4- dicarboxylate inhibitory manner. The Km and Vmax values for uptake were 8.6 mumol litre-1 and 1.7 nmol/min/mg protein and 2.2 mumol litre-1 and 0.7 nmol/min/mg protein in cortical and cerebellar preparations, respectively. At clinically relevant concentrations none of the agents tested influenced the uptake process. Our data suggest that the uptake of glutamate is not a major target site for anaesthetic or analgesic agents.
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