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British Journal of Anaesthesia, 1995, Vol. 74, No. 6 651-654
© 1995 The Board of Management and Trustees of the British Journal of Anaesthesia

other

Prediction of infusion rates of vecuronium using the bolus test dose technique

R. J. MORGAN, MB, CHB, DRCOG, FRCA and B. J. POLLARD, BPHARAM, MD, FRCA

University Department of Anaesthesia, Manchester Royal Infirmary Oxford Road, Manchester M13 9WL

Correspondence to B.J.P.

Fifty neurosurgical patients were given loading doses of vecuronium 0.1 mg kg–1 followed by boluses of 1, 2 or 4 mg after return of T1 of the train-of-four. Neuromuscular function was assessed simultaneously by palpation of the great toe after peripheral nerve stimulation of the lateral popliteal nerve using a handheld nerve stimulator and also using a Relaxograph attached to one arm. The time taken for the return of T1 after the bolus dose was recorded and an infusion of vecuronium was begun and subsequently adjusted to maintain steady state neuromuscular block. It was possible to predict the infusion rate of vecuronium from the duration of action of a 2-mg or 4-mg but not a 1-mg bolus dose using the handheld stimulator. The infusion rate could also be predicted from the duration of action of the initial loading dose.


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