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British Journal of Anaesthesia, 1992, Vol. 69, No. 5 487-491
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

INTERACTION BETWEEN HALOTHANE AND MU, DELTA AND KAPPA OPIOID AGONISTS ON THE ISOLATED RIGHT ATRIA OF THE RAT

J. A. MICOL, M.D.1 and M. L. LAORDEN, M.D., PH.D.2,*

1Department of Anesthesiology, Virgen de la Arrixaca Hospital Murcia, Spain
2Department of Physiology and Pharmacology School of Medicine Murcia, Spain

*Address for correspondence: Departamento de Farmacologia, Facultad de Medicina, 30100 Espinardo, Murcia, Espafia

We have examined the interaction between halo-thane and specific opioid agonists at mu (morphine and [D-ala2 N-mephe4, gly-ol5J-enkephalin (DAGO)), delta ([D-pen2 5]-enkephalin (DPDPE)) and kappa (trans-3,4-dichloro-N-methyl-N-[2-(1 -pyrrolikynyl)cyclohexyl]-bencetamidemethanesul-phonate (U-50,488H)) receptors on the isolated right atria of the rat. All the opioid agonists tested decreased atrial rate. The maximal effects obtained with U-50A88H (75 (SE 3.3)%) were significantly (P < 0.001) greater than those obtained with morphine (12(2.7)<), DAGO (8(0.6)<) or DPDPE (11 (1:8)<). Halothane 1.5 v/% did not modify the inhibitory effects induced by morphine, DAGO or DPDPE. However, U-50,488H had a potentiating effect in the presence of halothane 1.5 v/v% (P<0.001). Naloxone 5 x 1O–7 and 1 x 1O–6 mol litre–1 antagonized the inhibitory effects of U-50,488H in the presence of halothane. We conclude that halothane increased the potency of a kappa agonist on isolated right atria and suggest that this effect was meded by opioid receptors. (Br. J. Anaesth. 1992; 69:487–491)


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