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British Journal of Anaesthesia, 1992, Vol. 69, No. 5 478-481
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

HEPATIC DISPOSITION OF METHOHEXITONE IN PATIENTS UNDERGOING CORONARY BYPASS SURGERY

H. LANGE, M.D.1, H. STEPHAN, M.D., C. BRAND, S. ZIELMANN, M.D. and H. SONNTAG, M.D.

Department of Anesthesiology, University of Goettingen Robert Koch Str. 40, D-3400 Goettingen, Germany

1Correspondence to H.L.

In order to clarify the relative contribution of hepatic metabolism to the short term disposition of metho-hexitone, we have measured hepatic blood flow during induction of anaesthesia with a 1.5-mg kg–1 i. v. bolus dose of methohexitone. Median hepatic clearance was 1.01 litre min–1 and hepatic extraction 87%. As a consequence of the high hepatic extraction, the hepatic clearance of methohexitone was closely dependent on hepatic plasma flow. (Br. J. Anaesth. 1992; 69: 478–481)


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